In-Line and In-Situ Characterization
Developing multimodal in-line and in-situ analytics, including UV/Vis, Raman, FTIR, and other orthogonal sensors, to generate rich data streams for real-time monitoring and AI-driven experimentation in flow systems.
Overview
Real-time characterization is essential for understanding reaction kinetics, structural evolution, and product quality in continuous-flow systems. Our work focuses on analytical modules that can be embedded directly into flow reactors to provide immediate feedback on both chemical composition and structure. By combining in-line UV–Vis, Raman, and FTIR spectroscopy and other orthogonal sensing modalities, we aim to build the information backbone required for high-throughput screening and autonomous exploration of reaction and materials spaces.
Research Objectives
- •Develop in-line UV-Vis spectroscopy methods for reaction monitoring and kinetic studies
- •Implement in-situ SAXS for real-time structural characterization of nanomaterials
- •Create data processing algorithms for real-time analysis of spectroscopic and scattering data
- •Integrate multiple analytical techniques for comprehensive process understanding
- •Enable closed-loop control systems based on real-time measurements
Applications
- •Kinetic studies of fast reactions and nanoparticle formation in flow systems
- •Real-time monitoring of nanoparticle size and morphology evolution
- •Quality control for continuous manufacturing processes
- •Detection and quantification of reaction intermediates and side products
- •Structure-property correlation studies for nanomaterials